Annotation Detail

Information
Associated Genes
APOE
Associated Variants
APOE p.Arg43Cys (p.R43C) ( ENST00000252486.9 )
APOE p.Arg43Cys (p.R43C) ( ENST00000252486.9 )
Associated Disease
Alzheimer disease 3 Sea-blue histiocyte syndrome Alzheimer disease 4 age related macular degeneration 1 Lipoprotein glomerulopathy Alzheimer disease 2 Familial type 3 hyperlipoproteinemia
Source Database
ClinVar
Description
NM_000041.4(APOE):c.127C>T (p.Arg43Cys) AND multiple conditions
ClinVar Allele ID
32919
ClinVar RefSeq Alternation Syntax
NM_001302690.2:c.127C>T
ClinVar RefSeq Alternation Syntax
NM_001302689.2:c.127C>T
ClinVar RefSeq Alternation Syntax
NM_001302691.2:c.127C>T
ClinVar RefSeq Alternation Syntax
NM_001302688.2:c.205C>T
ClinVar RefSeq Alternation Syntax
NM_000041.4:c.127C>T
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2022-02-24
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002496418
ClinVar Disease
Alzheimer disease 3
ClinVar Disease
Alzheimer disease 4
ClinVar Disease
Lipoprotein glomerulopathy
ClinVar Disease
Familial type 3 hyperlipoproteinemia
ClinVar Disease
Sea-blue histiocyte syndrome
ClinVar Disease
Alzheimer disease 2
ClinVar Disease
Age related macular degeneration 1
Observed Origin Sample
unknown
Drugs