Annotation Detail

Information
Associated Genes
PRNP
Associated Variants
PRNP p.Met232Arg (p.M232R) ( ENST00000424424.2, ENST00000379440.9, ENST00000430350.2, ENST00000457586.2 )
PRNP p.Met232Arg (p.M232R) ( ENST00000430350.2, ENST00000379440.9, ENST00000424424.2, ENST00000457586.2 )
Associated Disease
Kuru, susceptibility to Huntington disease-like 1 fatal familial insomnia Gerstmann-Straussler-Scheinker syndrome Inherited Creutzfeldt-Jakob disease Spongiform encephalopathy with neuropsychiatric features
Source Database
ClinVar
Description
NM_000311.5(PRNP):c.695T>G (p.Met232Arg) AND multiple conditions
ClinVar Allele ID
28445
ClinVar RefSeq Alternation Syntax
NM_001080122.3:c.695T>G
ClinVar RefSeq Alternation Syntax
NM_001080121.3:c.695T>G
ClinVar RefSeq Alternation Syntax
NM_183079.4:c.695T>G
ClinVar RefSeq Alternation Syntax
NM_001080123.3:c.695T>G
ClinVar RefSeq Alternation Syntax
NM_000311.5:c.695T>G
ClinVar RefSeq Alternation Syntax
NM_001271561.3:c.*384T>G
Clinical Significance Description
Uncertain significance
Clinical Significance Last Update
2021-12-02
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002496357
ClinVar Disease
Kuru, susceptibility to
ClinVar Disease
Spongiform encephalopathy with neuropsychiatric features
ClinVar Disease
Gerstmann-Straussler-Scheinker syndrome
ClinVar Disease
Fatal familial insomnia
ClinVar Disease
Huntington disease-like 1
ClinVar Disease
Inherited Creutzfeldt-Jakob disease
Observed Origin Sample
unknown
Drugs