Annotation Detail

Information
Associated Genes
WFS1
Associated Variants
WFS1 p.Pro504Leu (p.P504L) ( ENST00000226760.5, ENST00000503569.5, ENST00000506362.2, ENST00000673991.1, ENST00000682275.1, ENST00000684087.1 )
WFS1 p.Pro504Leu (p.P504L) ( ENST00000226760.5, ENST00000503569.5, ENST00000506362.2, ENST00000673991.1, ENST00000682275.1, ENST00000684087.1 )
Associated Disease
Wolfram syndrome 1 cataract 41 type 2 diabetes mellitus Autosomal dominant nonsyndromic hearing loss 6 Wolfram-like syndrome
Source Database
ClinVar
Description
NM_006005.3(WFS1):c.1511C>T (p.Pro504Leu) AND multiple conditions
ClinVar Allele ID
19551
ClinVar RefSeq Alternation Syntax
NM_001145853.1:c.1511C>T
ClinVar RefSeq Alternation Syntax
NM_006005.3:c.1511C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-04-17
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002496259
ClinVar Disease
Wolfram syndrome 1
ClinVar Disease
Cataract 41
ClinVar Disease
Type 2 diabetes mellitus
ClinVar Disease
Wolfram-like syndrome
ClinVar Disease
Autosomal dominant nonsyndromic hearing loss 6
Observed Origin Sample
unknown
Drugs