Annotation Detail

Information
Associated Genes
COL2A1
Associated Variants
COL2A1 p.Arg515= (p.R515=) ( ENST00000337299.7, ENST00000380518.8 )
COL2A1 p.Arg515= (p.R515=) ( ENST00000337299.7, ENST00000380518.8 )
Associated Disease
Stickler syndrome, type I, nonsyndromic ocular Legg-Calve-Perthes disease Stickler syndrome type 1 Multiple epiphyseal dysplasia, Beighton type Spondyloepiphyseal dysplasia, Stanescu type Avascular necrosis of femoral head, primary, 1 spondyloperipheral dysplasia Spondylometaphyseal dysplasia - Sutcliffe type spondyloepiphyseal dysplasia congenita Namaqualand hip dysplasia Vitreoretinopathy with phalangeal epiphyseal dysplasia Spondyloepiphyseal dysplasia with metatarsal shortening spondyloepimetaphyseal dysplasia, Strudwick type achondrogenesis type II Kniest dysplasia Platyspondylic dysplasia, Torrance type
Source Database
ClinVar
Description
NM_001844.5(COL2A1):c.1545C>A (p.Arg515=) AND multiple conditions
ClinVar Allele ID
254554
ClinVar RefSeq Alternation Syntax
NM_001844.5:c.1545C>A
ClinVar RefSeq Alternation Syntax
NM_033150.3:c.1338C>A
Clinical Significance Description
Benign
Clinical Significance Last Update
2021-08-09
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002494733
ClinVar Disease
Platyspondylic dysplasia, Torrance type
ClinVar Disease
Namaqualand hip dysplasia
ClinVar Disease
Stickler syndrome type 1
ClinVar Disease
Legg-Calve-Perthes disease
ClinVar Disease
Spondylometaphyseal dysplasia - Sutcliffe type
ClinVar Disease
Spondyloepiphyseal dysplasia with metatarsal shortening
ClinVar Disease
Multiple epiphyseal dysplasia, Beighton type
ClinVar Disease
Spondyloperipheral dysplasia
ClinVar Disease
Stickler syndrome, type I, nonsyndromic ocular
ClinVar Disease
Achondrogenesis type II
ClinVar Disease
Spondyloepiphyseal dysplasia, Stanescu type
ClinVar Disease
Spondyloepimetaphyseal dysplasia, Strudwick type
ClinVar Disease
Kniest dysplasia
ClinVar Disease
Spondyloepiphyseal dysplasia congenita
ClinVar Disease
Vitreoretinopathy with phalangeal epiphyseal dysplasia
ClinVar Disease
Avascular necrosis of femoral head, primary, 1
Observed Origin Sample
unknown
Drugs