Annotation Detail

Information
Associated Genes
LMNA
Associated Variants
LMNA c.1608+1G>A ( ENST00000368297.5, ENST00000473598.6, ENST00000683032.1, ENST00000677389.1, ENST00000368301.6, ENST00000675667.1, ENST00000675939.1, ENST00000676385.2, ENST00000368300.9, ENST00000682650.1, ENST00000504687.7, ENST00000448611.6, ENST00000361308.9, ENST00000368299.7 )
LMNA c.1608+1G>A ( ENST00000361308.9, ENST00000368297.5, ENST00000368299.7, ENST00000368300.9, ENST00000368301.6, ENST00000448611.6, ENST00000473598.6, ENST00000504687.7, ENST00000675667.1, ENST00000675939.1, ENST00000676385.2, ENST00000677389.1, ENST00000682650.1, ENST00000683032.1 )
Associated Disease
Familial partial lipodystrophy, Dunnigan type Hutchinson-Gilford syndrome Charcot-Marie-Tooth disease type 2B1 Emery-Dreifuss muscular dystrophy 3, autosomal recessive restrictive dermopathy 2 Heart-hand syndrome, Slovenian type congenital muscular dystrophy due to LMNA mutation dilated cardiomyopathy 1A Mandibuloacral dysplasia with type A lipodystrophy dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome Emery-Dreifuss muscular dystrophy 2, autosomal dominant
Source Database
ClinVar
Description
NM_170707.4(LMNA):c.1608+1G>A AND multiple conditions
ClinVar Allele ID
77750
ClinVar RefSeq Alternation Syntax
NM_001406995.1:c.1050+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406990.1:c.1050+1G>A
ClinVar RefSeq Alternation Syntax
NM_001282626.2:c.1608+1G>A
ClinVar RefSeq Alternation Syntax
NM_005572.4:c.1608+1G>A
ClinVar RefSeq Alternation Syntax
NM_001407003.1:c.1050+1G>A
ClinVar RefSeq Alternation Syntax
NM_001257374.3:c.1272+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406992.1:c.1608+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406993.1:c.1050+1G>A
ClinVar RefSeq Alternation Syntax
NM_170708.4:c.1608+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406985.1:c.1608+1G>A
ClinVar RefSeq Alternation Syntax
NM_001407000.1:c.984+1G>A
ClinVar RefSeq Alternation Syntax
NM_001407001.1:c.984+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406999.1:c.984+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406994.1:c.984+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406997.1:c.1050+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406983.1:c.1608+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406989.1:c.1272+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406986.1:c.1365+1G>A
ClinVar RefSeq Alternation Syntax
NM_001282625.2:c.1608+1G>A
ClinVar RefSeq Alternation Syntax
NM_001282624.2:c.1365+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406996.1:c.1050+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406988.1:c.1311+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406991.1:c.1608+1G>A
ClinVar RefSeq Alternation Syntax
NM_001407002.1:c.1050+1G>A
ClinVar RefSeq Alternation Syntax
NM_170707.4:c.1608+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406998.1:c.1272+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406984.1:c.1608+1G>A
ClinVar RefSeq Alternation Syntax
NM_001406987.1:c.1365+1G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-05-18
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002490641
ClinVar Disease
Emery-Dreifuss muscular dystrophy 2, autosomal dominant
ClinVar Disease
Emery-Dreifuss muscular dystrophy 3, autosomal recessive
ClinVar Disease
Familial partial lipodystrophy, Dunnigan type
ClinVar Disease
Heart-hand syndrome, Slovenian type
ClinVar Disease
Charcot-Marie-Tooth disease type 2B1
ClinVar Disease
Hutchinson-Gilford syndrome
ClinVar Disease
Congenital muscular dystrophy due to LMNA mutation
ClinVar Disease
Dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome
ClinVar Disease
Restrictive dermopathy 2
ClinVar Disease
Mandibuloacral dysplasia with type A lipodystrophy
ClinVar Disease
Dilated cardiomyopathy 1A
Observed Origin Sample
unknown
Drugs