Annotation Detail

Information
Associated Genes
FGFR3
Associated Variants
FGFR3 p.Ter809Leuext*? (p.*809Lext*?) ( ENST00000340107.9, ENST00000352904.6, ENST00000412135.7, ENST00000440486.8, ENST00000481110.7 )
FGFR3 p.Ter809Leuext*? (p.*809Lext*?) ( ENST00000340107.9, ENST00000352904.6, ENST00000412135.7, ENST00000440486.8, ENST00000481110.7 )
Associated Disease
Thanatophoric dysplasia type 1 colorectal cancer Severe achondroplasia-developmental delay-acanthosis nigricans syndrome Levy-Hollister syndrome Germ cell tumor of testis achondroplasia hypochondroplasia Malignant tumor of urinary bladder Crouzon syndrome-acanthosis nigricans syndrome epidermal nevus camptodactyly-tall stature-scoliosis-hearing loss syndrome Muenke Syndrome cervical cancer Thanatophoric dysplasia, type 2
Source Database
ClinVar
Description
NM_000142.5(FGFR3):c.2420G>T (p.Ter807Leu) AND multiple conditions
ClinVar Allele ID
76470
ClinVar RefSeq Alternation Syntax
NM_001354809.2:c.2423G>T
ClinVar RefSeq Alternation Syntax
NR_148971.2:n.2846G>T
ClinVar RefSeq Alternation Syntax
NM_001354810.2:c.2352G>T
ClinVar RefSeq Alternation Syntax
NM_022965.4:c.2084G>T
ClinVar RefSeq Alternation Syntax
NM_001163213.2:c.2426G>T
ClinVar RefSeq Alternation Syntax
NM_000142.5:c.2420G>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-02-14
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002490635
ClinVar Disease
Thanatophoric dysplasia type 1
ClinVar Disease
Crouzon syndrome-acanthosis nigricans syndrome
ClinVar Disease
Muenke syndrome
ClinVar Disease
Camptodactyly-tall stature-scoliosis-hearing loss syndrome
ClinVar Disease
Colorectal cancer
ClinVar Disease
Severe achondroplasia-developmental delay-acanthosis nigricans syndrome
ClinVar Disease
Epidermal nevus
ClinVar Disease
Achondroplasia
ClinVar Disease
Hypochondroplasia
ClinVar Disease
Malignant tumor of urinary bladder
ClinVar Disease
Thanatophoric dysplasia, type 2
ClinVar Disease
Germ cell tumor of testis
ClinVar Disease
Cervical cancer
ClinVar Disease
Levy-Hollister syndrome
Observed Origin Sample
unknown
Drugs