Annotation Detail

Information
Associated Genes
MSH2
Associated Variants
MSH2 p.Asn127Ser (p.N127S) ( ENST00000406134.5, ENST00000233146.7, ENST00000543555.6, ENST00000645506.1, ENST00000713854.1, ENST00000713860.1, ENST00000713861.1, ENST00000713919.1 )
MSH2 p.Asn127Ser (p.N127S) ( ENST00000233146.7, ENST00000406134.5, ENST00000543555.6, ENST00000645506.1, ENST00000713854.1, ENST00000713860.1, ENST00000713861.1, ENST00000713919.1 )
Associated Disease
Mismatch repair cancer syndrome 2 Muir-Torré syndrome Lynch syndrome 1
Source Database
ClinVar
Description
NM_000251.3(MSH2):c.380A>G (p.Asn127Ser) AND multiple conditions
ClinVar Allele ID
45239
ClinVar RefSeq Alternation Syntax
NM_001258281.1:c.182A>G
ClinVar RefSeq Alternation Syntax
NM_000251.3:c.380A>G
Clinical Significance Description
Likely benign
Clinical Significance Last Update
2022-04-23
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002490419
ClinVar Disease
Lynch syndrome 1
ClinVar Disease
Mismatch repair cancer syndrome 2
ClinVar Disease
Muir-Torré syndrome
Observed Origin Sample
unknown
Drugs