Annotation Detail

Information
Associated Genes
PRNP
Associated Variants
PRNP p.Met129Val (p.M129V) ( ENST00000379440.9, ENST00000430350.2, ENST00000457586.2, ENST00000424424.2 )
PRNP p.Met129Val (p.M129V) ( ENST00000430350.2, ENST00000457586.2, ENST00000424424.2, ENST00000379440.9 )
Associated Disease
fatal familial insomnia Spongiform encephalopathy with neuropsychiatric features Huntington disease-like 1 Inherited Creutzfeldt-Jakob disease Kuru, susceptibility to Gerstmann-Straussler-Scheinker syndrome
Source Database
ClinVar
Description
NM_000311.5(PRNP):c.385A>G (p.Met129Val) AND multiple conditions
ClinVar Allele ID
28436
ClinVar RefSeq Alternation Syntax
NM_001271561.3:c.*74A>G
ClinVar RefSeq Alternation Syntax
NM_001080121.3:c.385A>G
ClinVar RefSeq Alternation Syntax
NM_001080122.3:c.385A>G
ClinVar RefSeq Alternation Syntax
NM_000311.5:c.385A>G
ClinVar RefSeq Alternation Syntax
NM_001080123.3:c.385A>G
ClinVar RefSeq Alternation Syntax
NM_183079.4:c.385A>G
Clinical Significance Description
Benign
Clinical Significance Last Update
2021-07-22
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002490365
ClinVar Disease
Kuru, susceptibility to
ClinVar Disease
Spongiform encephalopathy with neuropsychiatric features
ClinVar Disease
Gerstmann-Straussler-Scheinker syndrome
ClinVar Disease
Fatal familial insomnia
ClinVar Disease
Huntington disease-like 1
ClinVar Disease
Inherited Creutzfeldt-Jakob disease
Observed Origin Sample
unknown
Drugs