Annotation Detail

Information
Associated Genes
RUNX2
Associated Variants
RUNX2 p.Arg225Gln (p.R225Q) ( ENST00000371432.7, ENST00000576263.5, ENST00000371436.10, ENST00000359524.7, ENST00000371438.5, ENST00000625924.1, ENST00000647337.2 )
RUNX2 p.Arg225Gln (p.R225Q) ( ENST00000359524.7, ENST00000371432.7, ENST00000371436.10, ENST00000371438.5, ENST00000576263.5, ENST00000625924.1, ENST00000647337.2 )
Associated Disease
Cleidocranial dysostosis Metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome
Source Database
ClinVar
Description
NM_001024630.4(RUNX2):c.674G>A (p.Arg225Gln) AND multiple conditions
ClinVar Allele ID
24341
ClinVar RefSeq Alternation Syntax
NM_001278478.2:c.632G>A
ClinVar RefSeq Alternation Syntax
NM_001369405.1:c.632G>A
ClinVar RefSeq Alternation Syntax
NM_001024630.4:c.674G>A
ClinVar RefSeq Alternation Syntax
NM_001015051.4:c.674G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-02-18
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002482851
ClinVar Disease
Cleidocranial dysostosis
ClinVar Disease
Metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome
Observed Origin Sample
unknown
Drugs