Annotation Detail

Information
Associated Genes
FGFR3
Associated Variants
FGFR3 p.Pro250Arg (p.P250R) ( ENST00000340107.9, ENST00000412135.7, ENST00000352904.6, ENST00000440486.8, ENST00000481110.7 )
FGFR3 p.Pro250Arg (p.P250R) ( ENST00000340107.9, ENST00000352904.6, ENST00000412135.7, ENST00000440486.8, ENST00000481110.7 )
Associated Disease
colorectal cancer Severe achondroplasia-developmental delay-acanthosis nigricans syndrome epidermal nevus Crouzon syndrome-acanthosis nigricans syndrome camptodactyly-tall stature-scoliosis-hearing loss syndrome Thanatophoric dysplasia type 1 Germ cell tumor of testis Levy-Hollister syndrome achondroplasia cervical cancer Muenke Syndrome Malignant tumor of urinary bladder Thanatophoric dysplasia, type 2 hypochondroplasia
Source Database
ClinVar
Description
NM_000142.5(FGFR3):c.749C>G (p.Pro250Arg) AND multiple conditions
ClinVar Allele ID
31379
ClinVar RefSeq Alternation Syntax
NM_000142.5:c.749C>G
ClinVar RefSeq Alternation Syntax
NM_001354810.2:c.749C>G
ClinVar RefSeq Alternation Syntax
NM_001163213.2:c.749C>G
ClinVar RefSeq Alternation Syntax
NM_001354809.2:c.749C>G
ClinVar RefSeq Alternation Syntax
NR_148971.2:n.1024C>G
ClinVar RefSeq Alternation Syntax
NM_022965.4:c.749C>G
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2021-10-21
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002476986
ClinVar Disease
Thanatophoric dysplasia type 1
ClinVar Disease
Crouzon syndrome-acanthosis nigricans syndrome
ClinVar Disease
Muenke syndrome
ClinVar Disease
Camptodactyly-tall stature-scoliosis-hearing loss syndrome
ClinVar Disease
Colorectal cancer
ClinVar Disease
Severe achondroplasia-developmental delay-acanthosis nigricans syndrome
ClinVar Disease
Epidermal nevus
ClinVar Disease
Achondroplasia
ClinVar Disease
Hypochondroplasia
ClinVar Disease
Malignant tumor of urinary bladder
ClinVar Disease
Thanatophoric dysplasia, type 2
ClinVar Disease
Germ cell tumor of testis
ClinVar Disease
Cervical cancer
ClinVar Disease
Levy-Hollister syndrome
Observed Origin Sample
unknown
Drugs