Annotation Detail

Information
Associated Genes
HBB LOC106099062 LOC107133510 LOC110006319
Associated Variants
HBB c.315+1G>A ( ENST00000335295.4, ENST00000485743.1, ENST00000647020.1 )
HBB c.315+1G>A ( ENST00000335295.4, ENST00000485743.1, ENST00000647020.1 )
Associated Disease
alpha thalassemia Methemoglobinemia, beta-globin type Beta-thalassemia HBB/LCRB Hb SS disease Erythrocytosis, familial, 6 Dominant beta-thalassemia Heinz body anemia Malaria, susceptibility to Hereditary persistence of fetal hemoglobin
Source Database
ClinVar
Description
NM_000518.5(HBB):c.315+1G>A AND multiple conditions
ClinVar Allele ID
30477
ClinVar RefSeq Alternation Syntax
NM_000518.5:c.315+1G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-01-13
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002476979
ClinVar Disease
Hereditary persistence of fetal hemoglobin
ClinVar Disease
Beta-thalassemia HBB/LCRB
ClinVar Disease
Hb SS disease
ClinVar Disease
alpha Thalassemia
ClinVar Disease
Malaria, susceptibility to
ClinVar Disease
Erythrocytosis, familial, 6
ClinVar Disease
Dominant beta-thalassemia
ClinVar Disease
Heinz body anemia
ClinVar Disease
Methemoglobinemia, beta-globin type
Observed Origin Sample
unknown
Drugs