Annotation Detail

Information
Associated Genes
HBB LOC106099062 LOC107133510
Associated Variants
HBB p.Gln40Ter (p.Q40*) ( ENST00000485743.1, ENST00000335295.4, ENST00000647020.1 )
HBB p.Gln40Ter (p.Q40*) ( ENST00000335295.4, ENST00000485743.1, ENST00000647020.1 )
Associated Disease
Hereditary persistence of fetal hemoglobin Malaria, susceptibility to Hb SS disease Beta-thalassemia HBB/LCRB Heinz body anemia Methemoglobinemia, beta-globin type Dominant beta-thalassemia Erythrocytosis, familial, 6 alpha thalassemia
Source Database
ClinVar
Description
NM_000518.5(HBB):c.118C>T (p.Gln40Ter) AND multiple conditions
ClinVar Allele ID
30441
ClinVar RefSeq Alternation Syntax
NM_000518.5:c.118C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-02-01
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002476976
ClinVar Disease
Hereditary persistence of fetal hemoglobin
ClinVar Disease
Beta-thalassemia HBB/LCRB
ClinVar Disease
Hb SS disease
ClinVar Disease
alpha Thalassemia
ClinVar Disease
Malaria, susceptibility to
ClinVar Disease
Erythrocytosis, familial, 6
ClinVar Disease
Dominant beta-thalassemia
ClinVar Disease
Heinz body anemia
ClinVar Disease
Methemoglobinemia, beta-globin type
Observed Origin Sample
unknown
Drugs