Annotation Detail

Information
Associated Genes
HBB LOC107133510 LOC110006319
Associated Variants
HBB p.Glu122Lys (p.E122K) ( ENST00000647020.1, ENST00000335295.4 )
HBB p.Glu122Lys (p.E122K) ( ENST00000335295.4, ENST00000647020.1 )
Associated Disease
Hb SS disease Malaria, susceptibility to Hereditary persistence of fetal hemoglobin Heinz body anemia Beta-thalassemia HBB/LCRB Dominant beta-thalassemia alpha thalassemia Methemoglobinemia, beta-globin type Erythrocytosis, familial, 6
Source Database
ClinVar
Description
NM_000518.4(HBB):c.364G>A (p.Glu122Lys) AND multiple conditions
ClinVar Disease
Heinz body anemia
ClinVar Allele ID
30331
ClinVar RefSeq Alternation Syntax
NM_000518.5:c.364G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-03-25
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002476974
ClinVar Disease
Hereditary persistence of fetal hemoglobin
ClinVar Disease
Beta-thalassemia HBB/LCRB
ClinVar Disease
Hb SS disease
ClinVar Disease
alpha Thalassemia
ClinVar Disease
Malaria, susceptibility to
ClinVar Disease
Erythrocytosis, familial, 6
ClinVar Disease
Dominant beta-thalassemia
ClinVar Disease
Methemoglobinemia, beta-globin type
Observed Origin Sample
unknown
Drugs