Annotation Detail

Information
Associated Genes
PTEN
Associated Variants
PTEN p.Arg308Cys (p.R308C) ( ENST00000371953.8, ENST00000688308.1, ENST00000700029.2, ENST00000713839.1, ENST00000700021.1, ENST00000472832.3 )
PTEN p.Arg308Cys (p.R308C) ( ENST00000371953.8, ENST00000472832.3, ENST00000688308.1, ENST00000700021.1, ENST00000700029.2, ENST00000713839.1 )
Associated Disease
Cowden syndrome 1 familial meningioma macrocephaly-autism syndrome Glioma susceptibility 2 Malignant tumor of prostate
Source Database
ClinVar
Description
NM_000314.8(PTEN):c.922C>T (p.Arg308Cys) AND multiple conditions
ClinVar Allele ID
408005
ClinVar RefSeq Alternation Syntax
NM_001304717.5:c.1441C>T
ClinVar RefSeq Alternation Syntax
NM_001304718.2:c.331C>T
ClinVar RefSeq Alternation Syntax
NM_000314.8:c.922C>T
Clinical Significance Description
Uncertain significance
Clinical Significance Last Update
2021-12-22
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002475934
ClinVar Disease
Cowden syndrome 1
ClinVar Disease
Malignant tumor of prostate
ClinVar Disease
Familial meningioma
ClinVar Disease
Glioma susceptibility 2
ClinVar Disease
Macrocephaly-autism syndrome
Observed Origin Sample
unknown
Drugs