Annotation Detail

Information
Associated Genes
GNB1
Associated Variants
GNB1 p.Ala73Thr (p.A73T) ( ENST00000703701.1, ENST00000610897.4, ENST00000703694.1, ENST00000703706.1, ENST00000703697.1, ENST00000703709.1, ENST00000703700.1, ENST00000703710.1, ENST00000378609.9, ENST00000703707.1, ENST00000703711.1, ENST00000615252.5, ENST00000703704.1, ENST00000703696.1, ENST00000703705.1, ENST00000703693.1, ENST00000703708.1, ENST00000703692.1, ENST00000703699.1, ENST00000703702.1, ENST00000703703.1 )
GNB1 p.Ala73Thr (p.A73T) ( ENST00000378609.9, ENST00000610897.4, ENST00000615252.5, ENST00000703692.1, ENST00000703693.1, ENST00000703694.1, ENST00000703696.1, ENST00000703697.1, ENST00000703699.1, ENST00000703700.1, ENST00000703701.1, ENST00000703702.1, ENST00000703703.1, ENST00000703704.1, ENST00000703705.1, ENST00000703706.1, ENST00000703707.1, ENST00000703708.1, ENST00000703709.1, ENST00000703710.1, ENST00000703711.1 )
Associated Disease
Global developmental delay-neuro-ophthalmological abnormalities-seizures-intellectual disability syndrome
Source Database
ClinVar
Description
NM_002074.5(GNB1):c.217G>A (p.Ala73Thr) AND Global developmental delay-neuro-ophthalmological abnormalities-seizures-intellectual disability syndrome
ClinVar Allele ID
1706549
ClinVar RefSeq Alternation Syntax
NM_001282539.2:c.217G>A
ClinVar RefSeq Alternation Syntax
NM_002074.5:c.217G>A
ClinVar RefSeq Alternation Syntax
NM_001282538.2:c.-84G>A
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2022-10-04
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002287623
ClinVar Disease
Global developmental delay-neuro-ophthalmological abnormalities-seizures-intellectual disability syndrome
Observed Origin Sample
de novo
Drugs