Annotation Detail

Information
Associated Genes
GJB2
Associated Variants
GJB2 p.Asp50Asn (p.D50N) ( ENST00000382848.5, ENST00000382844.2 )
GJB2 p.Asp50Asn (p.D50N) ( ENST00000382844.2, ENST00000382848.5 )
Associated Disease
Ichthyosis, hystrix-like, with hearing loss Autosomal dominant keratitis-ichthyosis-hearing loss syndrome
Source Database
ClinVar
Description
NM_004004.6(GJB2):c.148G>A (p.Asp50Asn) AND multiple conditions
ClinVar Allele ID
32059
ClinVar RefSeq Alternation Syntax
NM_004004.6:c.148G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-02-15
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002243652
ClinVar Disease
Autosomal dominant keratitis-ichthyosis-hearing loss syndrome
ClinVar Disease
Ichthyosis, hystrix-like, with hearing loss
Observed Origin Sample
germline
Drugs