Annotation Detail

Information
Associated Genes
PTEN
Associated Variants
PTEN p.Trp274Ter (p.W274*) ( ENST00000472832.3, ENST00000688308.1, ENST00000713839.1, ENST00000700021.1, ENST00000700029.2, ENST00000371953.8 )
PTEN p.Trp274Ter (p.W274*) ( ENST00000371953.8, ENST00000472832.3, ENST00000688308.1, ENST00000700021.1, ENST00000700029.2, ENST00000713839.1 )
Associated Disease
Cowden syndrome 1
Source Database
ClinVar
Description
NM_000314.8(PTEN):c.822G>A (p.Trp274Ter) AND Cowden syndrome 1
ClinVar Allele ID
152354
ClinVar RefSeq Alternation Syntax
NM_000314.8:c.822G>A
ClinVar RefSeq Alternation Syntax
NM_001304717.5:c.1341G>A
ClinVar RefSeq Alternation Syntax
NM_001304718.2:c.231G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-10-02
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002055846
ClinVar Disease
Cowden syndrome 1
Observed Origin Sample
germline
Observed Origin Sample
unknown
Drugs