Annotation Detail

Information
Associated Genes
GJB6
Associated Variants
GJB6 p.Arg143Gln (p.R143Q) ( ENST00000647243.1, ENST00000647029.1, ENST00000644283.1, ENST00000643211.1, ENST00000241124.11, ENST00000643121.1, ENST00000644667.1, ENST00000400065.7, ENST00000636852.1, ENST00000400066.8 )
GJB6 p.Arg143Gln (p.R143Q) ( ENST00000241124.11, ENST00000400065.7, ENST00000400066.8, ENST00000636852.1, ENST00000643121.1, ENST00000643211.1, ENST00000644283.1, ENST00000644667.1, ENST00000647029.1, ENST00000647243.1 )
Associated Disease
Autosomal dominant nonsyndromic hearing loss 3B Autosomal recessive nonsyndromic hearing loss 1A Autosomal recessive nonsyndromic hearing loss 1B Hidrotic ectodermal dysplasia syndrome
Source Database
ClinVar
Description
NM_001110219.3(GJB6):c.428G>A (p.Arg143Gln) AND multiple conditions
ClinVar Allele ID
1421868
ClinVar RefSeq Alternation Syntax
NM_001110220.3:c.428G>A
ClinVar RefSeq Alternation Syntax
NM_001370090.1:c.428G>A
ClinVar RefSeq Alternation Syntax
NM_001370091.1:c.428G>A
ClinVar RefSeq Alternation Syntax
NM_006783.5:c.428G>A
ClinVar RefSeq Alternation Syntax
NM_001370092.1:c.428G>A
ClinVar RefSeq Alternation Syntax
NM_001110221.3:c.428G>A
ClinVar RefSeq Alternation Syntax
NM_001110219.3:c.428G>A
Clinical Significance Description
Uncertain significance
Clinical Significance Last Update
2021-09-16
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001909862
ClinVar Disease
Autosomal recessive nonsyndromic hearing loss 1B
ClinVar Disease
Autosomal recessive nonsyndromic hearing loss 1A
ClinVar Disease
Autosomal dominant nonsyndromic hearing loss 3B
ClinVar Disease
Hidrotic ectodermal dysplasia syndrome
Observed Origin Sample
germline
Drugs