Annotation Detail

Information
Associated Genes
TMEM231
Associated Variants
TMEM231 p.Leu81Phe (p.L81F) ( ENST00000568377.5, ENST00000685935.1, ENST00000693682.1, ENST00000565067.5, ENST00000258173.11 )
TMEM231 p.Leu81Phe (p.L81F) ( ENST00000258173.11, ENST00000565067.5, ENST00000568377.5, ENST00000685935.1, ENST00000693682.1 )
Associated Disease
Meckel syndrome, type 11 Joubert syndrome 20
Source Database
ClinVar
Description
NM_001077418.3(TMEM231):c.241C>T (p.Leu81Phe) AND multiple conditions
ClinVar Allele ID
439090
ClinVar RefSeq Alternation Syntax
NR_074083.2:n.284C>T
ClinVar RefSeq Alternation Syntax
NM_001077416.2:c.400C>T
ClinVar RefSeq Alternation Syntax
NM_001077418.3:c.241C>T
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2023-12-18
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001865689
ClinVar Disease
Meckel syndrome, type 11
ClinVar Disease
Joubert syndrome 20
Observed Origin Sample
germline
Drugs