Annotation Detail

Information
Associated Genes
SPG7
Associated Variants
SPG7 p.Lys558Ter (p.K558*) ( ENST00000644781.1, ENST00000645818.2, ENST00000645897.1, ENST00000646716.1, ENST00000647079.1, ENST00000643649.1, ENST00000646303.1, ENST00000645063.1, ENST00000268704.7 )
SPG7 p.Lys558Ter (p.K558*) ( ENST00000268704.7, ENST00000643649.1, ENST00000644781.1, ENST00000645063.1, ENST00000645818.2, ENST00000645897.1, ENST00000646303.1, ENST00000646716.1, ENST00000647079.1 )
Associated Disease
hereditary spastic paraplegia
Source Database
ClinVar
Description
NM_003119.4(SPG7):c.1672A>T (p.Lys558Ter) AND Hereditary spastic paraplegia
ClinVar Allele ID
186292
ClinVar RefSeq Alternation Syntax
NM_003119.4:c.1672A>T
ClinVar RefSeq Alternation Syntax
NM_001363850.1:c.1672A>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2016-12-12
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001847793
ClinVar Disease
Hereditary spastic paraplegia
Observed Origin Sample
germline
Drugs