Annotation Detail

Information
Associated Genes
SPG7
Associated Variants
SPG7 p.Gly349Ser (p.G349S) ( ENST00000643649.1, ENST00000341316.6, ENST00000647079.1, ENST00000646303.1, ENST00000645063.1, ENST00000268704.7, ENST00000645818.2, ENST00000644781.1, ENST00000646716.1, ENST00000643307.1, ENST00000645897.1 )
SPG7 p.Gly349Ser (p.G349S) ( ENST00000268704.7, ENST00000341316.6, ENST00000643307.1, ENST00000643649.1, ENST00000644781.1, ENST00000645063.1, ENST00000645818.2, ENST00000645897.1, ENST00000646303.1, ENST00000646716.1, ENST00000647079.1 )
Associated Disease
hereditary spastic paraplegia
Source Database
ClinVar
Description
NM_003119.4(SPG7):c.1045G>A (p.Gly349Ser) AND Hereditary spastic paraplegia
ClinVar Allele ID
21858
ClinVar RefSeq Alternation Syntax
NM_199367.3:c.1045G>A
ClinVar RefSeq Alternation Syntax
NM_003119.4:c.1045G>A
ClinVar RefSeq Alternation Syntax
NM_001363850.1:c.1045G>A
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2019-02-01
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001847595
ClinVar Disease
Hereditary spastic paraplegia
Observed Origin Sample
germline
Drugs