Annotation Detail

Information
Associated Genes
AK2
Associated Variants
AK2 c.499-2_499-1insAC ( ENST00000354858.11, ENST00000480134.5, ENST00000672715.1, ENST00000467905.5, ENST00000373449.7, ENST00000548033.5 )
AK2 c.499-2_499-1insAC ( ENST00000354858.11, ENST00000373449.7, ENST00000467905.5, ENST00000480134.5, ENST00000548033.5, ENST00000672715.1 )
Associated Disease
Severe combined immunodeficiency disease
Source Database
ClinVar
Description
NM_001625.4(AK2):c.498_499dup (p.Ile167fs) AND Severe combined immunodeficiency disease
ClinVar Allele ID
1330891
ClinVar RefSeq Alternation Syntax
NM_001319140.2:c.354_355dup
ClinVar RefSeq Alternation Syntax
NM_001319142.3:c.372_373dup
ClinVar RefSeq Alternation Syntax
NM_001319139.3:c.354_355dup
ClinVar RefSeq Alternation Syntax
NM_013411.5:c.498_499dup
ClinVar RefSeq Alternation Syntax
NM_001319141.3:c.498_499dup
ClinVar RefSeq Alternation Syntax
NM_001625.4:c.498_499dup
ClinVar RefSeq Alternation Syntax
NM_001319143.2:c.*1_*2dup
ClinVar RefSeq Alternation Syntax
NR_134976.3:n.458_459dup
ClinVar RefSeq Alternation Syntax
NM_001199199.3:c.474_475dup
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2022-01-11
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001825068
ClinVar Disease
Severe combined immunodeficiency disease
Observed Origin Sample
germline
Drugs