Annotation Detail

Information
Associated Genes
GLB1
Associated Variants
GLB1 p.Arg590His (p.R590H) ( ENST00000307363.10, ENST00000307377.12, ENST00000399402.7 )
GLB1 p.Arg590His (p.R590H) ( ENST00000307363.10, ENST00000307377.12, ENST00000399402.7 )
Associated Disease
GM1 gangliosidosis type 3 Infantile GM1 gangliosidosis GM1 gangliosidosis type 2
Source Database
ClinVar
Description
NM_000404.4(GLB1):c.1769G>A (p.Arg590His) AND multiple conditions
ClinVar Allele ID
98808
ClinVar RefSeq Alternation Syntax
NM_001135602.3:c.1376G>A
ClinVar RefSeq Alternation Syntax
NM_001317040.2:c.1913G>A
ClinVar RefSeq Alternation Syntax
NM_001079811.3:c.1679G>A
ClinVar RefSeq Alternation Syntax
NM_001393580.1:c.1734+16746G>A
ClinVar RefSeq Alternation Syntax
NM_000404.4:c.1769G>A
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2021-11-03
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001810420
ClinVar Disease
GM1 gangliosidosis type 3
ClinVar Disease
GM1 gangliosidosis type 2
ClinVar Disease
Infantile GM1 gangliosidosis
Observed Origin Sample
unknown
Drugs