Annotation Detail

Information
Associated Genes
HBB LOC107133510 LOC110006319
Associated Variants
HBB p.Lys133TrpfsTer4 (p.K133Wfs*4) ( ENST00000647020.1, ENST00000335295.4 )
HBB p.Lys133TrpfsTer4 (p.K133Wfs*4) ( ENST00000335295.4, ENST00000647020.1 )
HBB p.Ala129ProfsTer12 (p.A129Pfs*12) ( ENST00000335295.4, ENST00000647020.1 )
HBB p.Ala129ProfsTer12 (p.A129Pfs*12) ( ENST00000335295.4, ENST00000647020.1 )
Associated Disease
Dominant beta-thalassemia
Source Database
ClinVar
Description
NM_000518.5(HBB):c.[385_388delinsCCACA;397_407del] AND Dominant beta-thalassemia
ClinVar Allele ID
30648
ClinVar Allele ID
857434
ClinVar RefSeq Alternation Syntax
NM_000518.5:c.397_407del
ClinVar RefSeq Alternation Syntax
NM_000518.5:c.385_388delinsCCACA
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2010-06-03
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001789787
ClinVar Disease
Dominant beta-thalassemia
Observed Origin Sample
germline
Pubmed
20233970
Pubmed
1971109
Pubmed
4361439
Drugs