Annotation Detail

Information
Associated Genes
RYR1
Associated Variants
RYR1 p.Val4849Ile (p.V4849I) ( ENST00000355481.8, ENST00000359596.8, ENST00000689936.2, ENST00000713952.1, ENST00000713953.1 )
RYR1 p.Val4849Ile (p.V4849I) ( ENST00000355481.8, ENST00000359596.8, ENST00000689936.2, ENST00000713952.1, ENST00000713953.1 )
Source Database
ClinVar
Description
NM_000540.3(RYR1):c.14545G>A (p.Val4849Ile) AND enflurane response - Toxicity
ClinVar Allele ID
28023
ClinVar RefSeq Alternation Syntax
NM_000540.3:c.14545G>A
ClinVar RefSeq Alternation Syntax
NM_001042723.2:c.14530G>A
Clinical Significance Description
drug response
Clinical Significance Last Update
2021-03-24
Clinical Significance Review Status
reviewed by expert panel
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001787790
Observed Origin Sample
germline
Drugs