Annotation Detail

Information
Associated Genes
HBB LOC106099062 LOC107133510
Associated Variants
HBB p.Glu7Lys (p.E7K) ( ENST00000485743.1, ENST00000335295.4, ENST00000647020.1 )
HBB p.Glu7Lys (p.E7K) ( ENST00000335295.4, ENST00000485743.1, ENST00000647020.1 )
Associated Disease
Hb SS disease Erythrocytosis, familial, 6 Methemoglobinemia, beta-globin type Fetal hemoglobin quantitative trait locus 1 beta thalassemia Heinz body anemia Malaria, susceptibility to alpha thalassemia Dominant beta-thalassemia
Source Database
ClinVar
Description
NM_000518.4(HBB):c.19G>A (p.Glu7Lys) AND multiple conditions
ClinVar Allele ID
30165
ClinVar RefSeq Alternation Syntax
NM_000518.5:c.19G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2021-06-30
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001535943
ClinVar Disease
Hb SS disease
ClinVar Disease
alpha Thalassemia
ClinVar Disease
Fetal hemoglobin quantitative trait locus 1
ClinVar Disease
Malaria, susceptibility to
ClinVar Disease
Erythrocytosis, familial, 6
ClinVar Disease
Dominant beta-thalassemia
ClinVar Disease
Heinz body anemia
ClinVar Disease
beta Thalassemia
ClinVar Disease
Methemoglobinemia, beta-globin type
Observed Origin Sample
unknown
Drugs