Annotation Detail

Information
Associated Genes
RAG1
Associated Variants
RAG1 p.Lys820Arg (p.K820R) ( ENST00000299440.6, ENST00000697713.1, ENST00000697714.1, ENST00000697715.1 )
RAG1 p.Lys820Arg (p.K820R) ( ENST00000299440.6, ENST00000697713.1, ENST00000697714.1, ENST00000697715.1 )
Associated Disease
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive Combined immunodeficiency with skin granulomas
Source Database
ClinVar
Description
NM_000448.3(RAG1):c.2459A>G (p.Lys820Arg) AND multiple conditions
ClinVar Allele ID
254149
ClinVar RefSeq Alternation Syntax
NM_001377278.1:c.2459A>G
ClinVar RefSeq Alternation Syntax
NM_000448.3:c.2459A>G
ClinVar RefSeq Alternation Syntax
NM_001377277.1:c.2459A>G
ClinVar RefSeq Alternation Syntax
NM_001377279.1:c.2459A>G
ClinVar RefSeq Alternation Syntax
NM_001377280.1:c.2459A>G
Clinical Significance Description
Benign
Clinical Significance Last Update
2024-02-01
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001512872
ClinVar Disease
Combined immunodeficiency with skin granulomas
ClinVar Disease
Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive
Observed Origin Sample
germline
Drugs