Annotation Detail

Information
Associated Genes
HBB LOC107133510 LOC110006319
Associated Variants
HBB p.Val127Glu (p.V127E) ( ENST00000647020.1, ENST00000335295.4 )
HBB p.Val127Glu (p.V127E) ( ENST00000335295.4, ENST00000647020.1 )
Associated Disease
beta thalassemia
Source Database
ClinVar
Description
NM_000518.5(HBB):c.380T>A (p.Val127Glu) AND beta Thalassemia
ClinVar Allele ID
30240
ClinVar RefSeq Alternation Syntax
NM_000518.5:c.380T>A
Clinical Significance Description
Likely pathogenic
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001507092
ClinVar Disease
beta Thalassemia
Observed Origin Sample
germline
Drugs