Annotation Detail

Information
Associated Genes
SMPD1
Associated Variants
SMPD1 p.Leu304Pro (p.L304P) ( ENST00000527275.5, ENST00000342245.9 )
SMPD1 p.Leu304Pro (p.L304P) ( ENST00000342245.9, ENST00000527275.5 )
Associated Disease
Niemann-Pick disease, type B Niemann-Pick disease, type A
Source Database
ClinVar
Description
NM_000543.5(SMPD1):c.911T>C (p.Leu304Pro) AND multiple conditions
ClinVar Allele ID
18028
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2024-01-08
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001380607
ClinVar Disease
Niemann-Pick disease, type A
ClinVar Disease
Niemann-Pick disease, type B
Observed Origin Sample
germline
Observed Origin Sample
unknown
Drugs