Annotation Detail

Information
Associated Genes
OPA1
Associated Variants
OPA1 p.Arg327Gln (p.R327Q) ( ENST00000361150.6, ENST00000361510.8, ENST00000361715.6, ENST00000361828.7, ENST00000361908.8, ENST00000392436.7, ENST00000392437.6, ENST00000643329.1, ENST00000645553.1, ENST00000646793.1 )
OPA1 p.Arg327Gln (p.R327Q) ( ENST00000361150.6, ENST00000361510.8, ENST00000361715.6, ENST00000361828.7, ENST00000361908.8, ENST00000392436.7, ENST00000392437.6, ENST00000643329.1, ENST00000645553.1, ENST00000646793.1 )
Associated Disease
Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
Source Database
ClinVar
Description
NM_130837.3(OPA1):c.1034G>A (p.Arg345Gln) AND Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
ClinVar Allele ID
20123
ClinVar RefSeq Alternation Syntax
NM_130836.3:c.980G>A
ClinVar RefSeq Alternation Syntax
NM_130834.3:c.923G>A
ClinVar RefSeq Alternation Syntax
NM_130832.3:c.815G>A
ClinVar RefSeq Alternation Syntax
NM_015560.3:c.869G>A
ClinVar RefSeq Alternation Syntax
NM_130837.3:c.1034G>A
ClinVar RefSeq Alternation Syntax
NM_130833.3:c.872G>A
ClinVar RefSeq Alternation Syntax
NM_130835.3:c.926G>A
ClinVar RefSeq Alternation Syntax
NM_001354664.2:c.497G>A
ClinVar RefSeq Alternation Syntax
NM_001354663.2:c.500G>A
ClinVar RefSeq Alternation Syntax
NM_130831.3:c.761G>A
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2018-07-18
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001336297
ClinVar Disease
Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
Observed Origin Sample
maternal
Drugs