Annotation Detail

Information
Associated Genes
SMPD1
Associated Variants
SMPD1 p.Arg602His (p.R602H) ( ENST00000527275.5, ENST00000342245.9 )
SMPD1 p.Arg602His (p.R602H) ( ENST00000342245.9, ENST00000527275.5 )
Associated Disease
Sphingomyelin/cholesterol lipidosis
Source Database
ClinVar
Description
NM_000543.5(SMPD1):c.1805G>A (p.Arg602His) AND Sphingomyelin/cholesterol lipidosis
ClinVar Allele ID
186828
ClinVar RefSeq Alternation Syntax
NM_001365135.2:c.1673G>A
ClinVar RefSeq Alternation Syntax
NR_027400.3:n.1758G>A
ClinVar RefSeq Alternation Syntax
NR_134502.2:n.1297G>A
ClinVar RefSeq Alternation Syntax
NM_001318087.2:c.*298G>A
ClinVar RefSeq Alternation Syntax
NM_000543.5:c.1805G>A
ClinVar RefSeq Alternation Syntax
NM_001007593.3:c.1802G>A
ClinVar RefSeq Alternation Syntax
NM_001318088.2:c.884G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-04-14
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001248877
ClinVar Disease
Sphingomyelin/cholesterol lipidosis
Observed Origin Sample
germline
Drugs