Annotation Detail

Information
Associated Genes
SMPD1
Associated Variants
SMPD1 p.Trp32Ter (p.W32*) ( ENST00000342245.9, ENST00000527275.5 )
SMPD1 p.Trp32Ter (p.W32*) ( ENST00000342245.9, ENST00000527275.5 )
Associated Disease
Niemann-Pick disease, type B
Source Database
ClinVar
Description
NM_000543.5(SMPD1):c.96G>A (p.Trp32Ter) AND Niemann-Pick disease, type B
ClinVar Allele ID
186823
ClinVar RefSeq Alternation Syntax
NM_000543.5:c.96G>A
ClinVar RefSeq Alternation Syntax
NM_001318088.2:c.-866G>A
ClinVar RefSeq Alternation Syntax
NM_001365135.2:c.96G>A
ClinVar RefSeq Alternation Syntax
NR_027400.3:n.221G>A
ClinVar RefSeq Alternation Syntax
NM_001007593.3:c.96G>A
ClinVar RefSeq Alternation Syntax
NM_001318087.2:c.96G>A
ClinVar RefSeq Alternation Syntax
NR_134502.2:n.221G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2020-05-01
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001199862
ClinVar Disease
Niemann-Pick disease, type B
Observed Origin Sample
germline
Drugs