Annotation Detail

Information
Associated Genes
LIG4
Associated Variants
LIG4 p.Ile658Val (p.I658V) ( ENST00000686913.1, ENST00000685338.1, ENST00000686095.1, ENST00000687164.1, ENST00000688595.1, ENST00000688396.1, ENST00000686204.1, ENST00000614526.2, ENST00000689762.1, ENST00000686926.1, ENST00000692222.1, ENST00000693040.1, ENST00000405925.2, ENST00000611712.4, ENST00000687822.1, ENST00000688455.1, ENST00000690127.1, ENST00000688529.1, ENST00000442234.6 )
LIG4 p.Ile658Val (p.I658V) ( ENST00000405925.2, ENST00000442234.6, ENST00000611712.4, ENST00000614526.2, ENST00000685338.1, ENST00000686095.1, ENST00000686204.1, ENST00000686913.1, ENST00000686926.1, ENST00000687164.1, ENST00000687822.1, ENST00000688396.1, ENST00000688455.1, ENST00000688529.1, ENST00000688595.1, ENST00000689762.1, ENST00000690127.1, ENST00000692222.1, ENST00000693040.1 )
Associated Disease
Severe combined immunodeficiency due to DCLRE1C deficiency
Source Database
ClinVar
Description
NM_206937.2(LIG4):c.1972A>G (p.Ile658Val) AND Severe combined immunodeficiency due to DCLRE1C deficiency
ClinVar Allele ID
684382
ClinVar RefSeq Alternation Syntax
NM_001352601.2:c.1972A>G
ClinVar RefSeq Alternation Syntax
NM_001352603.1:c.1972A>G
ClinVar RefSeq Alternation Syntax
NM_206937.2:c.1972A>G
ClinVar RefSeq Alternation Syntax
NM_001330595.2:c.1771A>G
ClinVar RefSeq Alternation Syntax
NM_001379095.1:c.1972A>G
ClinVar RefSeq Alternation Syntax
NM_001352600.2:c.1972A>G
ClinVar RefSeq Alternation Syntax
NM_001098268.2:c.1972A>G
ClinVar RefSeq Alternation Syntax
NM_001352599.2:c.1972A>G
ClinVar RefSeq Alternation Syntax
NM_002312.3:c.1972A>G
ClinVar RefSeq Alternation Syntax
NM_001352602.2:c.1972A>G
ClinVar RefSeq Alternation Syntax
NM_001352598.2:c.1972A>G
ClinVar RefSeq Alternation Syntax
NM_001352604.2:c.2008A>G
Clinical Significance Description
Benign
Clinical Significance Last Update
2017-04-27
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001112885
ClinVar Disease
Severe combined immunodeficiency due to DCLRE1C deficiency
Observed Origin Sample
germline
Drugs