Annotation Detail

Information
Associated Genes
GLB1
Associated Variants
GLB1 p.Arg148Ser (p.R148S) ( ENST00000307363.10, ENST00000307377.12, ENST00000399402.7 )
GLB1 p.Arg148Ser (p.R148S) ( ENST00000307363.10, ENST00000307377.12, ENST00000399402.7 )
Associated Disease
Mucopolysaccharidosis, MPS-IV-B GM1 gangliosidosis
Source Database
ClinVar
Description
NM_000404.4(GLB1):c.442C>A (p.Arg148Ser) AND multiple conditions
ClinVar Allele ID
543207
ClinVar RefSeq Alternation Syntax
NM_001393580.1:c.442C>A
ClinVar RefSeq Alternation Syntax
NM_001079811.3:c.352C>A
ClinVar RefSeq Alternation Syntax
NM_001135602.3:c.246-2688C>A
ClinVar RefSeq Alternation Syntax
NM_001317040.2:c.586C>A
ClinVar RefSeq Alternation Syntax
NM_000404.4:c.442C>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2024-01-31
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001055679
ClinVar Disease
Mucopolysaccharidosis, MPS-IV-B
ClinVar Disease
GM1 gangliosidosis
Observed Origin Sample
germline
Drugs