Annotation Detail

Information
Associated Genes
AIRE
Associated Variants
AIRE p.Ala264LeufsTer114 (p.A264Lfs*114) ( ENST00000291582.6 )
AIRE p.Ala264LeufsTer114 (p.A264Lfs*114) ( ENST00000291582.6 )
Associated Disease
Polyglandular autoimmune syndrome, type 1
Source Database
ClinVar
Description
NM_000383.4(AIRE):c.789del (p.Ala264fs) AND Polyglandular autoimmune syndrome, type 1
ClinVar Allele ID
18354
ClinVar RefSeq Alternation Syntax
NM_000383.4:c.789del
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-09-14
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001047339
ClinVar Disease
Polyglandular autoimmune syndrome, type 1
Observed Origin Sample
germline
Drugs