Annotation Detail

Information
Associated Genes
IRF6
Associated Variants
ENSG00000289700 p.Gln49Ter (p.Q49*), IRF6 p.Gln49Ter (p.Q49*) ( ENST00000367021.8, ENST00000542854.5 )
ENSG00000289700 p.Gln49Ter (p.Q49*), IRF6 p.Gln49Ter (p.Q49*) ( ENST00000367021.8, ENST00000542854.5 )
Associated Disease
popliteal pterygium syndrome Van der Woude syndrome Orofacial cleft 6, susceptibility to
Source Database
ClinVar
Description
NM_006147.4(IRF6):c.145C>T (p.Gln49Ter) AND multiple conditions
ClinVar Allele ID
48590
ClinVar RefSeq Alternation Syntax
NM_006147.4:c.145C>T
ClinVar RefSeq Alternation Syntax
NM_001206696.2:c.-112+4678C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2020-09-02
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001037238
ClinVar Disease
Orofacial cleft 6, susceptibility to
ClinVar Disease
Van der Woude syndrome
ClinVar Disease
Popliteal pterygium syndrome
Observed Origin Sample
germline
Drugs