Annotation Detail

Information
Associated Genes
EXT2
Associated Variants
EXT2 p.Tyr618Cys (p.Y618C) ( ENST00000533608.7, ENST00000395673.8, ENST00000682359.1, ENST00000343631.4, ENST00000358681.8, ENST00000683000.1, ENST00000684533.1, ENST00000682711.1 )
EXT2 p.Tyr618Cys (p.Y618C) ( ENST00000343631.4, ENST00000358681.8, ENST00000395673.8, ENST00000533608.7, ENST00000682359.1, ENST00000682711.1, ENST00000683000.1, ENST00000684533.1 )
Associated Disease
Seizures-scoliosis-macrocephaly syndrome
Source Database
ClinVar
Description
NM_207122.2(EXT2):c.1823A>G (p.Tyr608Cys) AND Seizures-scoliosis-macrocephaly syndrome
ClinVar Allele ID
626395
ClinVar RefSeq Alternation Syntax
NM_207122.2:c.1823A>G
ClinVar RefSeq Alternation Syntax
NM_000401.3:c.1922A>G
ClinVar RefSeq Alternation Syntax
NM_001178083.3:c.1853A>G
ClinVar RefSeq Alternation Syntax
NM_001389628.1:c.1823A>G
ClinVar RefSeq Alternation Syntax
NM_001389630.1:c.1823A>G
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2019-08-02
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000791304
ClinVar Disease
Seizures-scoliosis-macrocephaly syndrome
Observed Origin Sample
germline
Pubmed
30288735
Drugs