Annotation Detail

Information
Associated Genes
BRAF
Associated Variants
BRAF p.Lys539Glu (p.K539E) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
BRAF p.Lys539Glu (p.K539E) ( ENST00000288602.11, ENST00000646891.2, ENST00000496384.7, ENST00000644969.2 )
Associated Disease
RASopathy
Source Database
ClinVar
Description
NM_004333.6(BRAF):c.1495A>G (p.Lys499Glu) AND RASopathy
ClinVar Allele ID
29015
ClinVar RefSeq Alternation Syntax
NM_001378471.1:c.1384A>G
ClinVar RefSeq Alternation Syntax
NM_001378469.1:c.1429A>G
ClinVar RefSeq Alternation Syntax
NM_001378470.1:c.1393A>G
ClinVar RefSeq Alternation Syntax
NM_001378468.1:c.1495A>G
ClinVar RefSeq Alternation Syntax
NM_001374244.1:c.1615A>G
ClinVar RefSeq Alternation Syntax
NM_001378467.1:c.1504A>G
ClinVar RefSeq Alternation Syntax
NM_001354609.2:c.1495A>G
ClinVar RefSeq Alternation Syntax
NM_001378474.1:c.1495A>G
ClinVar RefSeq Alternation Syntax
NM_004333.6:c.1495A>G
ClinVar RefSeq Alternation Syntax
NM_001378473.1:c.1339A>G
ClinVar RefSeq Alternation Syntax
NM_001378475.1:c.1231A>G
ClinVar RefSeq Alternation Syntax
NM_001374258.1:c.1615A>G
ClinVar RefSeq Alternation Syntax
NM_001378472.1:c.1339A>G
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2018-04-09
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000779848
ClinVar Disease
RASopathy
Observed Origin Sample
germline
Drugs