Annotation Detail

Information
Associated Genes
FGFR3
Associated Variants
FGFR3 p.Asn720Ser (p.N720S) ( ENST00000352904.6, ENST00000340107.9, ENST00000440486.8, ENST00000412135.7, ENST00000481110.7 )
FGFR3 p.Asn720Ser (p.N720S) ( ENST00000340107.9, ENST00000352904.6, ENST00000412135.7, ENST00000440486.8, ENST00000481110.7 )
Associated Disease
hypochondroplasia cervical cancer achondroplasia Levy-Hollister syndrome Malignant tumor of urinary bladder Severe achondroplasia-developmental delay-acanthosis nigricans syndrome Muenke Syndrome Thanatophoric dysplasia, type 2 Carcinoma of colon epidermal nevus camptodactyly-tall stature-scoliosis-hearing loss syndrome Crouzon syndrome-acanthosis nigricans syndrome Malignant tumor of testis Thanatophoric dysplasia type 1
Source Database
ClinVar
Description
NM_000142.5(FGFR3):c.2153A>G (p.Asn718Ser) AND multiple conditions
ClinVar Allele ID
511532
ClinVar RefSeq Alternation Syntax
NR_148971.2:n.2579A>G
ClinVar RefSeq Alternation Syntax
NM_001354810.2:c.2085A>G
ClinVar RefSeq Alternation Syntax
NM_000142.5:c.2153A>G
ClinVar RefSeq Alternation Syntax
NM_001163213.2:c.2159A>G
ClinVar RefSeq Alternation Syntax
NM_001354809.2:c.2156A>G
ClinVar RefSeq Alternation Syntax
NM_022965.4:c.1817A>G
Clinical Significance Description
Uncertain significance
Clinical Significance Last Update
2018-10-31
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000765770
ClinVar Disease
Thanatophoric dysplasia type 1
ClinVar Disease
Carcinoma of colon
ClinVar Disease
Crouzon syndrome-acanthosis nigricans syndrome
ClinVar Disease
Muenke syndrome
ClinVar Disease
Camptodactyly-tall stature-scoliosis-hearing loss syndrome
ClinVar Disease
Severe achondroplasia-developmental delay-acanthosis nigricans syndrome
ClinVar Disease
Malignant tumor of testis
ClinVar Disease
Epidermal nevus
ClinVar Disease
Achondroplasia
ClinVar Disease
Hypochondroplasia
ClinVar Disease
Malignant tumor of urinary bladder
ClinVar Disease
Thanatophoric dysplasia, type 2
ClinVar Disease
Cervical cancer
ClinVar Disease
Levy-Hollister syndrome
Observed Origin Sample
unknown
Drugs