Annotation Detail

Information
Associated Genes
FBN1
Associated Variants
FBN1 p.Asp1238Asn (p.D1238N) ( ENST00000316623.10 )
FBN1 p.Asp1238Asn (p.D1238N) ( ENST00000316623.10 )
Associated Disease
acromicric dysplasia stiff skin syndrome MASS syndrome Weill-Marchesani syndrome 2, dominant Progeroid and marfanoid aspect-lipodystrophy syndrome Marfan syndrome Ectopia lentis 1, isolated, autosomal dominant geleophysic dysplasia 2
Source Database
ClinVar
Description
NM_000138.5(FBN1):c.3712G>A (p.Asp1238Asn) AND multiple conditions
ClinVar Allele ID
197723
ClinVar RefSeq Alternation Syntax
NM_000138.5:c.3712G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2018-10-31
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000763355
ClinVar Disease
MASS syndrome
ClinVar Disease
Weill-Marchesani syndrome 2, dominant
ClinVar Disease
Geleophysic dysplasia 2
ClinVar Disease
Ectopia lentis 1, isolated, autosomal dominant
ClinVar Disease
Acromicric dysplasia
ClinVar Disease
Progeroid and marfanoid aspect-lipodystrophy syndrome
ClinVar Disease
Marfan syndrome
ClinVar Disease
Stiff skin syndrome
Observed Origin Sample
unknown
Drugs