Annotation Detail

Information
Associated Genes
HBB LOC106099062 LOC107133510
Associated Variants
HBB p.Lys18Ter (p.K18*) ( ENST00000647020.1, ENST00000485743.1, ENST00000335295.4 )
HBB p.Lys18Ter (p.K18*) ( ENST00000335295.4, ENST00000485743.1, ENST00000647020.1 )
Associated Disease
beta thalassemia alpha thalassemia Malaria, susceptibility to Erythrocytosis, familial, 6 Methemoglobinemia, beta-globin type Hb SS disease Fetal hemoglobin quantitative trait locus 1 Dominant beta-thalassemia Heinz body anemia
Source Database
ClinVar
Description
NM_000518.5(HBB):c.52A>T (p.Lys18Ter) AND multiple conditions
ClinVar Disease
alpha Thalassemia
ClinVar Disease
Hb SS disease
ClinVar Allele ID
30440
ClinVar RefSeq Alternation Syntax
NM_000518.5:c.52A>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2018-10-31
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000763255
ClinVar Disease
Fetal hemoglobin quantitative trait locus 1
ClinVar Disease
Malaria, susceptibility to
ClinVar Disease
Erythrocytosis, familial, 6
ClinVar Disease
Dominant beta-thalassemia
ClinVar Disease
Heinz body anemia
ClinVar Disease
beta Thalassemia
ClinVar Disease
Methemoglobinemia, beta-globin type
Observed Origin Sample
unknown
Drugs