Annotation Detail

Information
Associated Genes
FGFR3
Associated Variants
FGFR3 p.Gly382Arg (p.G382R) ( ENST00000340107.9, ENST00000352904.6, ENST00000412135.7, ENST00000440486.8, ENST00000481110.7 )
FGFR3 p.Gly382Arg (p.G382R) ( ENST00000340107.9, ENST00000352904.6, ENST00000412135.7, ENST00000440486.8, ENST00000481110.7 )
Associated Disease
Carcinoma of colon Malignant tumor of urinary bladder cervical cancer achondroplasia hypochondroplasia Severe achondroplasia-developmental delay-acanthosis nigricans syndrome epidermal nevus Muenke Syndrome Crouzon syndrome-acanthosis nigricans syndrome camptodactyly-tall stature-scoliosis-hearing loss syndrome Levy-Hollister syndrome Thanatophoric dysplasia, type 2 Malignant tumor of testis Thanatophoric dysplasia type 1
Source Database
ClinVar
Description
NM_000142.5(FGFR3):c.1138G>A (p.Gly380Arg) AND multiple conditions
ClinVar Allele ID
31366
ClinVar RefSeq Alternation Syntax
NM_001354809.2:c.1138G>A
ClinVar RefSeq Alternation Syntax
NM_000142.5:c.1138G>A
ClinVar RefSeq Alternation Syntax
NR_148971.2:n.1564G>A
ClinVar RefSeq Alternation Syntax
NM_022965.4:c.931-432G>A
ClinVar RefSeq Alternation Syntax
NM_001163213.2:c.1144G>A
ClinVar RefSeq Alternation Syntax
NM_001354810.2:c.1138G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2018-10-31
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000763121
ClinVar Disease
Thanatophoric dysplasia type 1
ClinVar Disease
Carcinoma of colon
ClinVar Disease
Crouzon syndrome-acanthosis nigricans syndrome
ClinVar Disease
Muenke syndrome
ClinVar Disease
Camptodactyly-tall stature-scoliosis-hearing loss syndrome
ClinVar Disease
Severe achondroplasia-developmental delay-acanthosis nigricans syndrome
ClinVar Disease
Malignant tumor of testis
ClinVar Disease
Epidermal nevus
ClinVar Disease
Achondroplasia
ClinVar Disease
Hypochondroplasia
ClinVar Disease
Malignant tumor of urinary bladder
ClinVar Disease
Thanatophoric dysplasia, type 2
ClinVar Disease
Cervical cancer
ClinVar Disease
Levy-Hollister syndrome
Observed Origin Sample
unknown
Drugs