Annotation Detail

Information
Associated Genes
COL2A1
Associated Variants
COL2A1 p.Cys86Ter (p.C86*) ( ENST00000337299.7, ENST00000380518.8 )
COL2A1 p.Cys86Ter (p.C86*) ( ENST00000337299.7, ENST00000380518.8 )
Associated Disease
Namaqualand hip dysplasia Platyspondylic dysplasia, Torrance type Avascular necrosis of femoral head, primary, 1 achondrogenesis type II spondyloepiphyseal dysplasia congenita Kniest dysplasia Legg-Calve-Perthes disease spondylometaphyseal dysplasia spondyloperipheral dysplasia Stickler syndrome type 1 Spondyloepiphyseal dysplasia, Stanescu type Multiple epiphyseal dysplasia, Beighton type Stickler syndrome, type I, nonsyndromic ocular Spondyloepiphyseal dysplasia with metatarsal shortening
Source Database
ClinVar
Description
NM_001844.5(COL2A1):c.258C>A (p.Cys86Ter) AND multiple conditions
ClinVar Allele ID
192309
ClinVar RefSeq Alternation Syntax
NM_001844.5:c.258C>A
ClinVar RefSeq Alternation Syntax
NM_033150.3:c.86-1522C>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2018-10-31
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000762897
ClinVar Disease
Platyspondylic dysplasia, Torrance type
ClinVar Disease
Namaqualand hip dysplasia
ClinVar Disease
Stickler syndrome type 1
ClinVar Disease
Legg-Calve-Perthes disease
ClinVar Disease
Spondylometaphyseal dysplasia
ClinVar Disease
Spondyloepiphyseal dysplasia with metatarsal shortening
ClinVar Disease
Multiple epiphyseal dysplasia, Beighton type
ClinVar Disease
Spondyloperipheral dysplasia
ClinVar Disease
Stickler syndrome, type I, nonsyndromic ocular
ClinVar Disease
Achondrogenesis type II
ClinVar Disease
Spondyloepiphyseal dysplasia, Stanescu type
ClinVar Disease
Kniest dysplasia
ClinVar Disease
Spondyloepiphyseal dysplasia congenita
ClinVar Disease
Avascular necrosis of femoral head, primary, 1
Observed Origin Sample
unknown
Drugs