Annotation Detail

Information
Associated Genes
KCNQ1
Associated Variants
KCNQ1 p.Gly269Ser (p.G269S) ( ENST00000335475.6, ENST00000496887.7, ENST00000155840.12, ENST00000646564.2, ENST00000713725.1 )
KCNQ1 p.Gly269Ser (p.G269S) ( ENST00000155840.12, ENST00000335475.6, ENST00000496887.7, ENST00000646564.2, ENST00000713725.1 )
Associated Disease
Short QT syndrome type 2 Beckwith-Wiedemann syndrome Jervell and Lange-Nielsen syndrome 1 long QT syndrome 1 Atrial fibrillation, familial, 3
Source Database
ClinVar
Description
NM_000218.3(KCNQ1):c.805G>A (p.Gly269Ser) AND multiple conditions
ClinVar Allele ID
18183
ClinVar RefSeq Alternation Syntax
NM_000218.3:c.805G>A
ClinVar RefSeq Alternation Syntax
NM_181798.2:c.424G>A
ClinVar RefSeq Alternation Syntax
NM_001406837.1:c.535G>A
ClinVar RefSeq Alternation Syntax
NM_001406836.1:c.805G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2018-10-31
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000762834
ClinVar Disease
Beckwith-Wiedemann syndrome
ClinVar Disease
Long QT syndrome 1
ClinVar Disease
Jervell and Lange-Nielsen syndrome 1
ClinVar Disease
Atrial fibrillation, familial, 3
ClinVar Disease
Short QT syndrome type 2
Observed Origin Sample
unknown
Drugs