Annotation Detail

Information
Associated Genes
PTEN
Associated Variants
PTEN p.His196ThrfsTer3 (p.H196Tfs*3) ( ENST00000371953.8, ENST00000700029.2, ENST00000688308.1, ENST00000472832.3, ENST00000700021.1, ENST00000713839.1 )
PTEN p.His196ThrfsTer3 (p.H196Tfs*3) ( ENST00000371953.8, ENST00000472832.3, ENST00000688308.1, ENST00000700021.1, ENST00000700029.2, ENST00000713839.1 )
Associated Disease
PTEN hamartoma tumor syndrome
Source Database
ClinVar
Description
NM_000314.8(PTEN):c.586del (p.His196fs) AND PTEN hamartoma tumor syndrome
ClinVar Allele ID
22862
ClinVar RefSeq Alternation Syntax
NM_000314.8:c.586del
ClinVar RefSeq Alternation Syntax
NM_001304718.2:c.-6del
ClinVar RefSeq Alternation Syntax
NM_001304717.5:c.1105del
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2018-04-06
Clinical Significance Review Status
reviewed by expert panel
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000735262
ClinVar Disease
PTEN hamartoma tumor syndrome
Observed Origin Sample
germline
Drugs