Annotation Detail

Information
Associated Genes
TPM3
Associated Variants
TPM3 p.Ter286Serext*? (p.*286Sext*?) ( ENST00000368531.6, ENST00000302206.9, ENST00000368533.8, ENST00000611659.5, ENST00000651641.1, ENST00000271850.11, ENST00000368530.7, ENST00000330188.13, ENST00000328159.9, ENST00000323144.12 )
TPM3 p.Ter286Serext*? (p.*286Sext*?) ( ENST00000271850.11, ENST00000302206.9, ENST00000323144.12, ENST00000328159.9, ENST00000330188.13, ENST00000368530.7, ENST00000368531.6, ENST00000368533.8, ENST00000611659.5, ENST00000651641.1 )
Associated Disease
Congenital myopathy 4B, autosomal recessive Congenital myopathy with fiber type disproportion
Source Database
ClinVar
Description
NM_152263.4(TPM3):c.857A>C (p.Ter286Ser) AND multiple conditions
ClinVar Allele ID
27486
ClinVar RefSeq Alternation Syntax
NM_001349679.2:c.743+1367A>C
ClinVar RefSeq Alternation Syntax
NM_001364683.1:c.746A>C
ClinVar RefSeq Alternation Syntax
NM_001278189.2:c.743+1367A>C
ClinVar RefSeq Alternation Syntax
NM_001364680.2:c.775+2462A>C
ClinVar RefSeq Alternation Syntax
NM_001278190.2:c.601+2462A>C
ClinVar RefSeq Alternation Syntax
NM_001043352.2:c.664+2462A>C
ClinVar RefSeq Alternation Syntax
NM_001364681.2:c.775+2462A>C
ClinVar RefSeq Alternation Syntax
NM_001278191.2:c.394+2462A>C
ClinVar RefSeq Alternation Syntax
NM_153649.4:c.664+2462A>C
ClinVar RefSeq Alternation Syntax
NM_001043353.2:c.664+2462A>C
ClinVar RefSeq Alternation Syntax
NM_152263.4:c.857A>C
ClinVar RefSeq Alternation Syntax
NM_001364679.2:c.775+2462A>C
ClinVar RefSeq Alternation Syntax
NM_001364682.1:c.857A>C
ClinVar RefSeq Alternation Syntax
NM_001043351.2:c.664+2462A>C
ClinVar RefSeq Alternation Syntax
NM_001278188.2:c.466+2462A>C
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2023-10-11
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000707046
ClinVar Disease
Congenital myopathy 4B, autosomal recessive
ClinVar Disease
Congenital myopathy with fiber type disproportion
Observed Origin Sample
germline
Drugs