Annotation Detail

Information
Associated Genes
PRKDC
Associated Variants
PRKDC p.Trp2337Arg (p.W2337R) ( ENST00000314191.7, ENST00000338368.7 )
PRKDC p.Leu2337Pro (p.L2337P) ( ENST00000314191.7, ENST00000338368.7 )
Associated Disease
Severe combined immunodeficiency due to DNA-PKcs deficiency
Source Database
ClinVar
Description
NM_006904.7(PRKDC):c.7010T>C (p.Leu2337Pro) AND Severe combined immunodeficiency due to DNA-PKcs deficiency
ClinVar Allele ID
524206
ClinVar RefSeq Alternation Syntax
NM_001081640.2:c.7010T>C
ClinVar RefSeq Alternation Syntax
NM_006904.7:c.7010T>C
Clinical Significance Description
Uncertain significance
Clinical Significance Last Update
2023-12-06
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000652351
ClinVar Disease
Severe combined immunodeficiency due to DNA-PKcs deficiency
Observed Origin Sample
germline
Drugs