Annotation Detail

Information
Associated Genes
TPM3
Associated Variants
TPM3 p.Arg168Cys (p.R168C) ( ENST00000368533.8, ENST00000323144.12, ENST00000368530.7, ENST00000368531.6, ENST00000271850.11, ENST00000330188.13, ENST00000328159.9, ENST00000302206.9, ENST00000611659.5, ENST00000651641.1 )
TPM3 p.Arg168Cys (p.R168C) ( ENST00000271850.11, ENST00000302206.9, ENST00000323144.12, ENST00000328159.9, ENST00000330188.13, ENST00000368530.7, ENST00000368531.6, ENST00000368533.8, ENST00000611659.5, ENST00000651641.1 )
Associated Disease
Congenital myopathy with fiber type disproportion Congenital myopathy 4B, autosomal recessive
Source Database
ClinVar
Description
NM_152263.4(TPM3):c.502C>T (p.Arg168Cys) AND multiple conditions
ClinVar Allele ID
27493
ClinVar RefSeq Alternation Syntax
NM_001364679.2:c.502C>T
ClinVar RefSeq Alternation Syntax
NM_001278190.2:c.391C>T
ClinVar RefSeq Alternation Syntax
NM_001043353.2:c.391C>T
ClinVar RefSeq Alternation Syntax
NM_001043351.2:c.391C>T
ClinVar RefSeq Alternation Syntax
NM_001278188.2:c.193C>T
ClinVar RefSeq Alternation Syntax
NM_153649.4:c.391C>T
ClinVar RefSeq Alternation Syntax
NM_001278191.2:c.121C>T
ClinVar RefSeq Alternation Syntax
NM_001364683.1:c.391C>T
ClinVar RefSeq Alternation Syntax
NM_001043352.2:c.391C>T
ClinVar RefSeq Alternation Syntax
NM_001364681.2:c.502C>T
ClinVar RefSeq Alternation Syntax
NM_001364680.2:c.502C>T
ClinVar RefSeq Alternation Syntax
NM_001349679.2:c.391C>T
ClinVar RefSeq Alternation Syntax
NM_001278189.2:c.391C>T
ClinVar RefSeq Alternation Syntax
NM_001364682.1:c.502C>T
ClinVar RefSeq Alternation Syntax
NM_152263.4:c.502C>T
ClinVar RefSeq Alternation Syntax
NR_103461.2:n.490C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2024-01-19
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000637291
ClinVar Disease
Congenital myopathy 4B, autosomal recessive
ClinVar Disease
Congenital myopathy with fiber type disproportion
Observed Origin Sample
germline
Drugs