Annotation Detail

Information
Associated Genes
TTR
Associated Variants
TTR p.Tyr89His (p.Y89H) ( ENST00000237014.8, ENST00000610404.5, ENST00000649620.1 )
TTR p.Tyr89His (p.Y89H) ( ENST00000237014.8, ENST00000610404.5, ENST00000649620.1 )
Associated Disease
Familial amyloid neuropathy
Source Database
ClinVar
Description
NM_000371.4(TTR):c.265T>C (p.Tyr89His) AND Familial amyloid neuropathy
ClinVar Allele ID
28505
ClinVar RefSeq Alternation Syntax
NM_000371.4:c.265T>C
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2020-06-28
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000586493
ClinVar Disease
Familial amyloid neuropathy
Observed Origin Sample
germline
Observed Origin Sample
unknown
Pubmed
12771253
Drugs