Annotation Detail

Information
Associated Genes
RAF1
Associated Variants
RAF1 p.Ser259Thr (p.S259T) ( ENST00000251849.9, ENST00000442415.7, ENST00000685437.1, ENST00000685653.1, ENST00000687923.1, ENST00000688543.1, ENST00000689389.1, ENST00000690397.1, ENST00000690460.1, ENST00000691899.1, ENST00000692093.1, ENST00000693312.1 )
RAF1 p.Ser259Thr (p.S259T) ( ENST00000251849.9, ENST00000442415.7, ENST00000685437.1, ENST00000685653.1, ENST00000687923.1, ENST00000688543.1, ENST00000689389.1, ENST00000690397.1, ENST00000690460.1, ENST00000691899.1, ENST00000692093.1, ENST00000693312.1 )
Associated Disease
RASopathy
Source Database
ClinVar
Description
NM_002880.4(RAF1):c.775T>A (p.Ser259Thr) AND RASopathy
ClinVar Allele ID
49071
ClinVar RefSeq Alternation Syntax
NM_001354691.3:c.532T>A
ClinVar RefSeq Alternation Syntax
NR_148940.3:n.1106T>A
ClinVar RefSeq Alternation Syntax
NR_148942.3:n.1106T>A
ClinVar RefSeq Alternation Syntax
NM_001354689.3:c.775T>A
ClinVar RefSeq Alternation Syntax
NM_001354694.3:c.532T>A
ClinVar RefSeq Alternation Syntax
NM_001354695.3:c.433T>A
ClinVar RefSeq Alternation Syntax
NM_001354693.3:c.676T>A
ClinVar RefSeq Alternation Syntax
NM_001354692.3:c.532T>A
ClinVar RefSeq Alternation Syntax
NM_002880.4:c.775T>A
ClinVar RefSeq Alternation Syntax
NM_001354690.3:c.775T>A
ClinVar RefSeq Alternation Syntax
NR_148941.3:n.1106T>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2017-04-03
Clinical Significance Review Status
reviewed by expert panel
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000522675
ClinVar Disease
RASopathy
Observed Origin Sample
germline
Drugs